Cooperating cancer gene identification via oncogenic retrovirus- induced insertional mutagenesis
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چکیده
word count: 178 Manuscript word count: 4936 Blood First Edition Paper, prepublished online June 16, 2005; DOI 10.1182/blood-2004-12-4840 Copyright © 2005 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 23, 2013. bloodjournal.hematologylibrary.org From
منابع مشابه
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis.
Multiple cooperating mutations that deregulate different signaling pathways are required to induce cancer. Identifying these cooperating mutations is a prerequisite for developing better combinatorial therapies for treating cancer. Here we show that cooperating cancer mutations can be identified through oncogenic-retrovirus-induced insertional mutagenesis. Among 13 myeloid leukemias induced by ...
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Insertional mutagenesis has been used as a functional forward genetics screen for the identification of novel genes involved in the pathogenesis of human cancers. Different insertional mutagens have been successfully used to reveal new cancer genes. For example, retroviruses are integrating viruses with the capacity to induce the deregulation of genes in the neighborhood of the insertion site. ...
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